Migraine is a primary headache disorder characterized by recurrent headache, which is moderately serious. Generally, headache affects one half of the head, pulsed in nature, and lasts for two to 72 hours. The associated symptoms may include nausea, vomiting, and sensitivity to light, sound or odor. Pain is usually made worse than physical activity.

One-third of people have a rash: usually a short period of visual disturbances, indicating that the headache will soon happen. Sometimes, there may be few or no headaches with it. It is believed that due to the combination of environment and genetic factors, migraine occurs. About two-thirds of the cases run in families.

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Changing the level of hormones can also play a role, because migraines affect a little more boys than girls before puberty and two to three times more women than men. Usually, the risk of migraine decreases during pregnancy. The underlying mechanisms are not fully known. However, it is believed that it involves the brain's nerves and blood vessels.

The initial recommended treatment is to avoid medicines and triggers for simple pain medication such as ibuprofen and paracetamol (acetaminophen) with headache, nausea. Specific drugs such as triptan or ergotamines are used in those for whom simple pain medicines are not effective. Caffeine can be added up. Many medicines are useful to prevent attacks including metoprolol, valproate and topiramate.

Globally, almost 15% of people are affected by migraine. It often starts in puberty and is worst during middle age. In some women, they become less common after menopause. By 2016, it is one of the most common causes of disability. Early descriptions related to migraine are contained in ancient Egypt in the Ibbers Papyrus written around 1500 BC.

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